| Abstrakt: |
Objective. We report here a study seeking to identify the possible influences of measures of cellular immunity and neurobiological variables (frequency of seizures of different types and seizure severity) on comorbid psychopathological symptoms depending on interhemispheric asymmetry profile in patients with focal forms of epilepsy. Materials and methods. The study included 92 patients with epilepsy (38 men, 54 women, mean age 38.7 ± 8.45 years). Focal temporal lobe epilepsy was diagnosed in 36 patients, focal frontal epilepsy in 16, and temporofrontal epilepsy in 40. Severity was assessed for each type of seizure using the National Seizure Severity Scale (NHS3). Patients' mental status was assessed using the SCL-90 self-report scale. The Annett scale was used to assess the interhemispheric asymmetry profile. The numbers of cells of different lymphocyte clusters, including T-lymphocytes (CD3+), T-helpers (CD3+CD4+), T-cytotoxic (CD3+CD8+), T-NK (natural killers, CD3+CD16+CD56+), and B-lymphocytes (CD3–CD19+), were determined, along with the immunoregulatory index (CD4/CD8 ratio). Possible relationships between neurobiological and immune variables on the one hand and SCL-90 constructs on the other were identified by Spearman rank correlation analysis in left- and right-handed groups separately. Results. Differences were found between groups of epilepsy patients with right- and left-sided interhemispheric asymmetry profiles in terms of relationships between the frequency of seizures, their severity, and accompanying psychopathological variables on the one hand and between indicators of immunity and psychopathological constructs on the other. Neurobiological and immune variables in left-handers were found to determine the psychopathological structure of comorbid mental disorders. Conclusions. Concomitant psychopathological syndromes in patients with epilepsy based on clinical data and data on immunity can be predicted, but only in patients with a left-sided interhemispheric asymmetry profile. [ABSTRACT FROM AUTHOR] |
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