| Autor: |
Biswas, Dwaipayan, Kishore, Dakoju Ravi, Naveen, Jakkula, Satyanarayana, Gedu |
| Předmět: |
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| Zdroj: |
ChemistrySelect; 8/20/2024, Vol. 9 Issue 31, p1-8, 8p |
| Abstrakt: |
A transition metal‐free synthesis of alkylidene dihydroisobenzofurans from the ortho‐alkynyl allylic alcohols is reported herein. Notably, a simple base tBuOK is utilized for the 5‐exo‐dig cyclization and double bond isomerization of ortho‐alkynyl allylic alcohols to furnish alkylidene dihydrobenzofurans with Z‐stereoselectivity under shorter reaction times. In addition, the geometry of the double bonds was confirmed by 1D Selective Gradient NOESY and 2D NMR (NOESY) analysis. Furthermore, the effectuality of the ortho‐alkynyl allylic alcohols has been shown by extending to the one‐pot synthesis of indanones via aqueous acid‐mediated hydrolysis (ring‐opening) of in‐situ formed dihydroisobenzofurans followed by intramolecular condensation reaction under acidic conditions [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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