| Autor: |
Fatima, Fiza, N Shyam, N. D. V., Kumar, G. Kiran, Narayen, Vaishali, Konda, Paremala, Sree, Sangeetha |
| Předmět: |
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| Zdroj: |
Oral & Maxillofacial Pathology Journal; Jan-Jun2024, Vol. 15 Issue 1, p49-55, 7p |
| Abstrakt: |
Introduction: Oral squamous cell carcinoma constitutes over 90% malignancies of the oral cavity and is preceded by dysplastic changes of the epithelium. Many proteins have emerged as potential markers of progression of oral epithelial dysplasia (OED) and oral squamous cell carcinoma (OSCC), such as the cell adhesion protein E-cadherin, and angiogenic stimulant vascular endothelial growth factor (VEGF). Aim and objectives: To assess the role of E-cadherin and VEGF in progression of OED and OSCC by comparing their immunohistochemical expression in normal oral mucosa (NOM), OED and OSCC. Materials and methods: Ten cases each of NOM, mild, moderate and severe OED, and well, moderately and poorly differentiated OSCC were included in the study. The percentage of immunohistochemically stained cells and staining intensity of E-cadherin and VEGF were assessed. Results: There was a statistically significant decrease in percentage of E-cadherin positive cells and intensity of staining on progression from NOM to OED to OSCC. A statistically significant increase in percentage of VEGF positive cells and staining intensity was seen on progression from NOM to OED to OSCC. Conclusion: E-cadherin downregulation and enhanced expression of VEGF with increasing grades of OED and OSCC indicates their role in tumour angiogenesis and progression of OSCC. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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