| Autor: |
Sai, Surapaneni Keerthi, Deepthi, G., Manasa, Gouthu Devi, Sitamahalakshmi, K., Chaganti, Siri Sravani, Oshin, Mary |
| Předmět: |
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| Zdroj: |
Oral & Maxillofacial Pathology Journal; Jan-Jun2024, Vol. 15 Issue 1, p5-9, 5p |
| Abstrakt: |
Introduction: Lipids play a key role in the maintenance of cell integrity and are required for various biological functions like cell growth and division of normal as well as malignant tissues. The changes in lipid profile is known to be associated with various cancers. Also, various tobacco associated products are responsible for high rate of oxidation/ peroxidation of polyunsaturated fatty acids releasing peroxide radicals causing hypolipidemia. Aim: The aim of this study was to estimate and compare the lipid profile of patients with oral potentially malignant disorders (OPMD) and oral squamous cell carcinoma (OSCC) with healthy group. Material and Methods: The study includes 90 subjects with 30 healthy controls, 30 OPMD’s and 30 OSCC patients and their fasting blood samples were collected. By using a semi auto analyser the following were analysed: i) Total Cholesterol (TC) ii) Low density lipoproteins (LDL) iii) High density lipoproteins (HDL) iv) Very low-density lipoproteins (VLDL) v) Triglycerides (TG) vi) CHO/HDL ratio. The obtained results were statistically analysed using independent t-test and ANOVA test. Results: A statistically significant decrease in plasma TC, LDL and CHO/HDL ratio was observed among OPMD and OSCC groups than controls whereas significant decrease in serum VLDL and TG (p value <0.01) in poorly differentiated OSCC was seen. Conclusion: The study shows a relation between lipid variations and OPMD and OSCC which might be due to their utilization for new membrane biogenesis. Thus, lower lipid status might be a useful biomarker for early changes happening in neoplastic cells. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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