LAVAA: a lightweight association viewer across ailments.

Autor:	Fauman, Eric B, Keppo, Stella, Cerioli, Nicola, Vyas, Rupesh, Kurki, Mitja, Daly, Mark, Reeve, Mary Pat
Předmět:	BIOBANKS SINGLE nucleotide polymorphisms WEB services GENOME-wide association studies VISUALIZATION
Zdroj:	Bioinformatics Advances; 2023, Vol. 3 Issue 1, p1-5, 5p
Abstrakt:	Motivation Biobank scale genetic associations results over thousands of traits can be difficult to visualize and navigate. Results We have created LAVAA, a visualization web-application to generate genetic volcano plots for simultaneously considering the P -value, effect size, case counts, trait class and fine-mapping posterior probability at a single-nucleotide polymorphism (SNP) across a range of traits from a large set of genome-wide association study. We find that user interaction with association results in LAVAA can enrich and enhance the biological interpretation of individual loci. Availability and implementation LAVAA is available as a stand-alone web service (https://geneviz.aalto.fi/LAVAA/) and will be available in future releases of the finngen.fi website starting with release 10 in late 2023. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
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