| Autor: |
Abdallat, Mahmoud, Qaswal, Abdallah Barjas, Eftaiha, Majed, Qamar, Abdel Rahman, Alnajjar, Qusai, Sallam, Rawand, Kollab, Lara, Masa'deh, Mohammad, Amayreh, Anas, Mihyar, Hiba, Aboushakra, Hesham, Alkelani, Bayan, Owaimer, Rawan, Abd-Alhadi, Mohannad, Ireiqat, Salwa, Turk, Fahed, Daoud, Ahmad, Darawsheh, Bashar, Hiasat, Ahmad, Alhalaki, Majd |
| Předmět: |
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| Zdroj: |
AIMS Biophysics; 2024, Vol. 11 Issue 2, p1-45, 45p |
| Abstrakt: |
The mitochondrion is a vital intracellular organelle that is responsible for ATP production. It utilizes both the concentration gradient and the electrical potential of the inner mitochondrial membrane to drive the flow of protons from the intermembrane space to the matrix to generate ATP via ATP-synthase. However, the proton leak flow, which is mediated via the inner mitochondrial membrane and uncoupling proteins, can reduce the efficiency of ATP production. Protons can exhibit a quantum behavior within biological systems. However, the investigation of the quantum behavior of protons within the mitochondria is lacking particularly in the contribution to the proton leak. In the present study, we proposed a mathematical model of protons tunneling through the inner mitochondrial membrane and the mitochondrial carrier superfamily MCF including uncoupling proteins UCPs and the adenine nucleotide translocases ANTs. According to the model and its assumptions, the quantum tunneling of protons may contribute significantly to the proton leak if it is compared with the classical flow of protons. The quantum tunneling proton leak may depolarize the membrane potential, hence it may contribute to the physiological regulation of ATP synthesis and reactive oxygen species ROS production. In addition to that, the mathematical model of proton tunneling suggested that the proton-tunneling leak may depolarize the membrane potential to values beyond the physiological needs which in turn can harm the mitochondria and the cells. Moreover, we argued that the quantum proton leak might be more energetically favorable if it is compared with the classical proton leak. This may give the advantage for quantum tunneling of protons to occur since less energy is required to contribute significantly to the proton leak compared with the classical proton flow. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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