Development of the Binocular Circuit.

Autor: Herrera, Eloísa, Chédotal, Alain, Mason, Carol
Předmět:
Zdroj: Annual Review of Neuroscience; Jul2024, Vol. 47, p303-322, 16p
Abstrakt: Seeing in three dimensions is a major property of the visual system in mammals. The circuit underlying this property begins in the retina, from which retinal ganglion cells (RGCs) extend to the same or opposite side of the brain. RGC axons decussate to form the optic chiasm, then grow to targets in the thalamus and midbrain, where they synapse with neurons that project to the visual cortex. Here we review the cellular and molecular mechanisms of RGC axonal growth cone guidance across or away from the midline via receptors to cues in the midline environment. We present new views on the specification of ipsi- and contralateral RGC subpopulations and factors implementing their organization in the optic tract and termination in subregions of their targets. Lastly, we describe the functional and behavioral aspects of binocular vision, focusing on the mouse, and discuss recent discoveries in the evolution of the binocular circuit. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index