| Autor: |
Abela, Irene A, Hauser, Anthony, Schwarzmüller, Magdalena, Pasin, Chloé, Kusejko, Katharina, Epp, Selina, Cavassini, Matthias, Battegay, Manuel, Rauch, Andri, Calmy, Alexandra, Notter, Julia, Bernasconi, Enos, Fux, Christoph A, Leuzinger, Karoline, Perreau, Matthieu, Ramette, Alban, Gottschalk, Jochen, Schindler, Eméry, Wepf, Alexander, Marconato, Maddalena |
| Předmět: |
|
| Zdroj: |
Journal of Infectious Diseases; 8/15/2024, Vol. 230 Issue 2, pe292-e304, 13p |
| Abstrakt: |
Background Factors influencing susceptibility to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) remain to be resolved. Using data from the Swiss HIV Cohort Study on 6270 people with human immunodeficiency virus (HIV) and serologic assessment for SARS-CoV-2 and circulating human coronavirus (HCoV) antibodies, we investigated the association of HIV-related and general parameters with SARS-CoV-2 infection. Methods We analyzed SARS-CoV-2 polymerase chain reaction test results, COVID-19–related hospitalizations, and deaths reported to the Swiss HIV Cohort Study between 1 January 2020 and 31 December 2021. Antibodies to SARS-CoV-2 and HCoVs were determined in prepandemic (2019) and pandemic (2020) biobanked plasma samples and compared with findings in HIV-negative individuals. We applied logistic regression, conditional logistic regression, and bayesian multivariate regression to identify determinants of SARS-CoV-2 infection and antibody responses to SARS-CoV-2 in people with HIV. Results No HIV-1–related factors were associated with SARS-CoV-2 acquisition. High prepandemic HCoV antibodies were associated with a lower risk of subsequent SARS-CoV-2 infection and with higher SARS-CoV-2 antibody responses on infection. We observed a robust protective effect of smoking on SARS-CoV-2 infection risk (adjusted odds ratio, 0.46 [95% confidence interval,.38–.56]; P <.001), which occurred even in previous smokers and was highest for heavy smokers. Conclusions Our findings of 2 independent protective factors, smoking and HCoV antibodies, both affecting the respiratory environment, underscore the importance of the local immune milieu in regulating susceptibility to SARS-CoV-2. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
|
