| Autor: |
Scholte, Florine E M, Rodriguez, Sergio E, Welch, Stephen R, Davies, Katherine A, Genzer, Sarah C, Coleman-McCray, JoAnn D, Harmon, Jessica R, Sorvillo, Teresa E, Lo, Michael K, Karaaslan, Elif, Bergeron, Eric, Montgomery, Joel M, Spengler, Jessica R, Spiropoulou, Christina F |
| Předmět: |
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| Zdroj: |
Journal of Infectious Diseases; 8/15/2024, Vol. 230 Issue 2, p438-443, 6p |
| Abstrakt: |
Nipah virus (NiV) is a highly pathogenic paramyxovirus. The Syrian hamster model recapitulates key features of human NiV disease and is a critical tool for evaluating antivirals and vaccines. Here we describe longitudinal humoral immune responses in NiV-infected Syrian hamsters. Samples were obtained 1–28 days after infection and analyzed by ELISA, neutralization, and Fc-mediated effector function assays. NiV infection elicited robust antibody responses against the nucleoprotein and attachment glycoprotein. Levels of neutralizing antibodies were modest and only detectable in surviving animals. Fc-mediated effector functions were mostly observed in nucleoprotein-targeting antibodies. Antibody levels and activities positively correlated with challenge dose. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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