Immunogenicity of a peptide-based vaccine for measles: a pilot evaluation in a mouse model.

Autor:	Quach, Huy Quang, Ratishvili, Tamar, Haralambieva, Iana H., Ovsyannikova, Inna G., Poland, Gregory A., Kennedy, Richard B.
Předmět:	MEASLES vaccines VACCINE immunogenicity LABORATORY mice HLA histocompatibility antigens ANIMAL disease models T cell receptors
Zdroj:	Scientific Reports; 8/13/2024, Vol. 14 Issue 1, p1-9, 9p
Abstrakt:	Although neutralizing antibody is an established correlate of protection for measles, T cell-mediated responses play at least two critical roles in immunity to measles: first, through provision of 'help' enabling robust humoral immune responses; and second, through clearance of measles virus-infected cells. Previously, we identified 13 measles-derived peptides that bound to human leukocyte antigen (HLA) molecules in Priess cells infected with measles virus. In this study, we evaluated the immunogenicity of these peptides in a transgenic mouse model. Our results demonstrated that these peptides induced Th1-biased immune responses at varying levels. Of the 13 peptides, the top four immunogenic peptides were further selected for a viral challenge study in mice. A vaccine based on a combination of these four peptides reduced morbidity and weight loss after viral challenge compared to placebo. Our results emphasize the potential of T cell-mediated, peptide-based vaccines against measles. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
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