| Předmět: |
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| Zdroj: |
Obesity, Fitness & Wellness Week; 8/19/2024, p2321-2321, 1p |
| Abstrakt: |
Researchers at Universidad San Sebastian have published a study on the role of the immunoproteasome in hypothalamic neurons as a potential therapeutic strategy for high-fat diet-induced obesity and metabolic dysregulation. The study found that the immunoproteasome levels were increased in hypothalamic neurons of obese mice fed a high-fat diet. This increase was associated with decreased autophagy and disrupted insulin-glucose axis. The researchers also demonstrated that an immunoproteasome inhibitor prevented the imbalance in the insulin-glucose axis and preserved mitochondrial function. These findings provide valuable insights into the mechanisms underlying obesity-related metabolic diseases and offer potential avenues for developing novel therapeutic interventions. [Extracted from the article] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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