Findings from University of Massachusetts Provide New Insights into Prostate Cancer (Androgen Receptor Splice Variants Drive Castrationresistant Prostate Cancer Metastasis By Activating Distinct Transcriptional Programs).

Předmět:	DNA-binding proteins ANDROGEN receptors SCHOLARSHIPS STEROID receptors TRANSCRIPTION factors
Zdroj:	Cancer Weekly; 8/20/2024, p421-421, 1p
Abstrakt:	A recent study conducted by researchers at the University of Massachusetts has shed light on the role of androgen receptor splice variants in driving the metastatic progression of castration-resistant prostate cancer (CRPC). The study focused on the AR-V7 splice variant and found that it activates distinct transcriptional programs that are involved in epithelial-mesenchymal transition and metastasis. The researchers also discovered that phosphorylation of AR-V7 at Ser81 enhances its pro-metastasis function. These findings provide molecular insights into the mechanisms underlying the development and progression of CRPC. [Extracted from the article]
Databáze:	Complementary Index
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