The dynamics and longevity of circulating CD4+ memory T cells depend on cell age and not the chronological age of the host.

Autor: Bullock, M. Elise, Hogan, Thea, Williams, Cayman, Morris, Sinead, Nowicka, Maria, Sharjeel, Minahil, van Dorp, Christiaan, Yates, Andrew J., Seddon, Benedict
Předmět:
Zdroj: PLoS Biology; 8/13/2024, Vol. 22 Issue 8, p1-21, 21p
Abstrakt: Quantifying the kinetics with which memory T cell populations are generated and maintained is essential for identifying the determinants of the duration of immunity. The quality and persistence of circulating CD4 effector memory (TEM) and central memory (TCM) T cells in mice appear to shift with age, but it is unclear whether these changes are driven by the aging host environment, by cell age effects, or both. Here, we address these issues by combining DNA labelling methods, established fate-mapping systems, a novel reporter mouse strain, and mathematical models. Together, these allow us to quantify the dynamics of both young and established circulating memory CD4 T cell subsets, within both young and old mice. We show that that these cells and their descendents become more persistent the longer they reside within the TCM and TEM pools. This behaviour may limit memory CD4 T cell diversity by skewing TCR repertoires towards clones generated early in life, but may also compensate for functional defects in new memory cells generated in old age. The quality and longevity of CD4+ effector and central memory T cells change with age in mice. This study shows that these cells have longer lifespans and become more quiescent when the organism ages, but these properties depend on the age of the cells and not on the age of the host environment. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index
Externí odkaz:
Nepřihlášeným uživatelům se plný text nezobrazuje