| Abstrakt: |
The indenture of the green approach in synthesizing metal oxide nanoparticles has resulted in greater stoutness and favorable dimensions of nanoparticles since they are synthesized using a single-step process. In this study, using Pterolobium hexapetalum aqueous leaf extract (P. hexapetalum) as a precursor, zinc acetate was reduced to obtain zinc oxide nanoparticles (ZnO-NPs) using a green synthesis approach. The synthesized ZnO-NPs were characterized by UV-Vis, XRD, FT-IR, EDAX, and HR-TEM with an SAED pattern. According to the findings, the UV-visible spectra result showed an absorbance peak at 370 nm. The FT-IR study of the synthesized ZnO-NPs revealed the presence of various functional groups. The HR-TEM result displayed a spherical shape with a size of 10–93 nm for synthesized ZnO-NPs. The X-ray diffraction (P-XRD) spectra confirmed the crystalline nature of the synthesized ZnO-NPs. The outcome of the edax spectrum confirmed the high purity of the Zn element that was present in the synthesized ZnO-NPs. Hemolytic activity of the synthesized ZnO-NPs was carried out against human red blood cells (RBCs), and it appeared that ZnO-NPs had less toxicity with a lysis percentage of 0.6% at a higher dosage of 100 μg/mL. The synthesized ZnO-NPs showed excellent antibacterial activity against Pseudomonas aeruginosa (17.8 mm). The synthesized ZnO-NPs displayed significant antioxidant activity against the DPPH radical scavenging assay with an IC50 value of 118.14 μg/mL. The anticancer activity of the synthesized ZnO-NPs revealed superior activity against the breast cancer cell line (MCF-7) with an IC50 value of 22.91 μg/mL. Additionally, the synthesized ZnO-NPs exhibited outstanding larvicidal activity on Cx. quinquefasciatus larvae with LC50 and LC90 values of 4.178 mg/mL and 16.157 mg/mL, respectively. Thus, plant-based synthesized ZnO-NPs exhibited significant biological activities, and hence, they can be considered a potential source for the development of innovative drugs. [ABSTRACT FROM AUTHOR] |
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