Adverse In-Hospital Outcomes after Radical Prostatectomy in Leukemia History Patients.

Autor:	Falkenbach, Fabian, Di Bello, Francesco, Rodriguez Peñaranda, Natali, Longoni, Mattia, Marmiroli, Andrea, Le, Quynh Chi, Tian, Zhe, Goyal, Jordan A., Longo, Nicola, Micali, Salvatore, Briganti, Alberto, de Cobelli, Ottavio, Chun, Felix K. H., Saad, Fred, Shariat, Shahrokh F., Budäus, Lars, Graefen, Markus, Karakiewicz, Pierre I.
Předmět:	RISK assessment INSURANCE LYMPHADENECTOMY RADICAL prostatectomy HOSPITAL care MULTIPLE regression analysis DESCRIPTIVE statistics MULTIVARIATE analysis AGE distribution ACUTE kidney failure LEUKEMIA ODDS ratio ADVERSE health care events LENGTH of stay in hospitals DISEASE risk factors
Zdroj:	Cancers; Aug2024, Vol. 16 Issue 15, p2764, 9p
Abstrakt:	Simple Summary: Leukemia history affects some radical prostatectomy (RP) patients. While its prevalence and impact as an adverse risk factor are well-known in cardiac surgery, the number of RP patients with a leukemia history and their rate of adverse in-hospital outcomes are unknown. We identified RP patients with a leukemia history in a large-scale database. Patients with a leukemia history had higher rates of acute kidney injury, more frequent dialysis, and extended hospital stays compared to those without a leukemia history. Introduction: Leukemia history affects some radical prostatectomy (RP) patients. Although its prevalence and effect as an adverse risk factor are well known in cardiac surgery, the number of RP patients with a leukemia history, as well as their rate of adverse in-hospital outcomes, are unknown. Methods: We identified RP patients (National Inpatient Sample 2000–2019), stratified according to the presence or absence of a leukemia history. Descriptive analyses, propensity score matching (PSM, ratio 1:10), and multivariable logistic regression models were used. Results: Of 259,939 RP patients, 416 (0.2%) had a leukemia history. Their proportion increased from 0.1 to 0.2% covering the study span (p < 0.01). Leukemia history patients were older (median age, 64 vs. 62 years, p < 0.001). After PSM for age, insurance status, ethnicity, pelvic lymph node dissection, and Charlson Comorbidity Index, leukemia history RP patients exhibited higher rates of acute kidney injury (<2.6 vs. 0.9%; Odds Ratio [OR] 2.0, p = 0.02), more frequently underwent dialysis (3.6 vs. 1.9%; OR 1.9, p = 0.03), and more frequently had a length of stay exceeding one week (4.8 vs. 2.5%; OR 2.0, p = 0.006). Conclusions: Although leukemia history RP patients are rare, their numbers have increased. Renal complications and extended hospital stays are more frequent in those individuals. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
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