A naphthalimide-based fluorescent platform for endoplasmic reticulum targeted imaging.

Autor: Li, Yiwei, Zhang, Nan, Wang, Yan, Lu, Shanshan, Sheng, Jing, Liu, Xiangjun, Wei, Yongbiao, Shangguan, Dihua
Předmět:
Zdroj: Chemical Communications; 8/21/2024, Vol. 60 Issue 65, p8565-8568, 4p
Abstrakt: A series of naphthalimide dyes (TRNATR, MOTNAMOT, MPNAMP, TYNATY, PNAP and IZNAIZ) were designed and synthesized by altering the side chains of the naphthalimide. Without the need for ER-targeting groups, the first five dyes were found to specifically target the ER, likely due to their well-suited lipophilic properties. Furthermore, TRNATR and TYNATY were proven effective for studying ER stress, showing promise in tracking ER autophagy in living cells triggered by tunicamycin and nutritional starvation. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index