| Předmět: |
|
| Zdroj: |
Drug Week; 8/13/2024, p3407-3407, 1p |
| Abstrakt: |
A recent study conducted by researchers at the University of Brasilia focused on the effectiveness of combining the antifungal peptide ToAP2 with fluconazole in treating Candida albicans biofilms. Candida albicans is a fungus that can cause invasive candidiasis, a life-threatening disease commonly associated with hospitalization. The study found that the combination of ToAP2 and fluconazole demonstrated a synergistic effect in reducing the viability of C. albicans biofilms on various materials, such as 96-well plates and medical devices. The researchers also observed structural changes in the biofilms and changes in gene expression associated with membrane synthesis and efflux pumps. The findings suggest that this combination treatment has therapeutic potential and could be used to develop preventive tools for intravenous catheters. [Extracted from the article] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
|
