LsBOS utilizes oxalyl-CoA produced by LsAAE3 to synthesize β-ODAP in grass pea.

Autor:	Goldsmith, Moshe, Avram, Liat, Brandis, Alexander, Mehlman, Tevie, Ben-Dor, Shifra, Peleg, Yoav, Ben-Zeev, Efrat, Barbole, Ranjit S., Reich, Ziv
Předmět:	CHEMICAL reactions PLANT enzymes LEGUME farming CHOLIC acid ENZYME kinetics OXALIC acid
Zdroj:	Nature Communications; 8/8/2024, Vol. 15 Issue 1, p1-4, 4p
Abstrakt:	This article explores the synthesis of β-N-oxalyl-l-α,β-diaminopropionic acid (β-ODAP) in grass pea, a legume commonly grown in Asia and Africa. The authors present conflicting findings regarding the enzymes responsible for β-ODAP synthesis. They challenge a previous study's claim that the enzyme LsAAE3 is involved, instead proposing that LsBOS is responsible. The authors provide evidence supporting their own two-step mechanism for β-ODAP synthesis and refute the claim that LsAAE3 has evolved to repurpose its activity. Understanding the production of β-ODAP is crucial for developing grass pea cultivars without the neurotoxic compound. [Extracted from the article]
Databáze:	Complementary Index
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