| Autor: |
Нікітін, О. Д., Пасєчніков, С. П., Головко, С. В., Кордубайло, І. А., Нішкумай, О. І. |
| Předmět: |
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| Zdroj: |
Health of Man (2786-7323); 2023, Issue 4, p67-72, 6p |
| Abstrakt: |
The objective: to determine the bone mineral density (BMD), bone tissue quality index (TBS) and to analyze the salt transport in patients with and without urolithiasis. Materials and methods. For qualitatively assess of crystalluria, a study of salt transport was conducted. Evaluation of the structural and functional state of bone tissue was performed on the basis of the Ukrainian Osteoporosis Center of the State University "Institute of Gerontology named after D. F. Chebotareva of National Academy of Sciences of Ukraine" by X-ray absorptiometry of the "Hologic Discovery" apparatus. 80 persons (15 men and 65 women) were included in the study, the average age of the patients was 58 years. Study participants were divided into two groups depending on the presence of urolithiasis. I group (n=32) included patients without urolithiasis with somatic diseases in the remission stage, who had no signs of exclusion criteria. Osteoporosis was diagnosed in 9 (28.1%) women of this group. Patients with urolithiasis were included in the II group (n=48). Osteoporosis was diagnosed in 18 (37.5%) women and 3 (6.25%) men in this group. Results. It was established that 21 (26.2%) patients had BMD within the normal range, 29 (36.3%) patients had BMD abnormalities within the limits of osteopenia, and 30 (37.6%) patients had osteoporosis, namely: 27 (33.8%) women and 3 (3.8%) men. Analysis of BMD status demonstrated that normal densitometric values were comparable in both groups (31.2% without urolithiasis and 22.9% patients with nephrolithiasis; p>0.05). The incidence of osteopenia in patients with urolithiasis (33.3%) and without urolithiasis (40.7%) and the number of cases of detected osteoporosis also did not significantly differ (43.8% and 28.1%, respectively; p>0.05). During X-ray absorptiometry it was found that the TBS bone quality index was significantly lower in patients with urolithiasis (p<0.05). A comparative analysis of salt transport demonstrated that blood uric acid levels in patients with urolithiasis were significantly higher (p=0.02) than those in patients without nephrolithiasis. Conclusions. The results of the study indicate the need for ultrasound examination of the kidneys and salt transport when checking BMD in patients at risk of osteoporosis for early diagnosis of nephrolithiasis and correction of crystalluria. Since a decrease in TBS even with a normal BMD is also an increased risk factor for bone fractures, its timely identification and correction are extremely important in patients with nephrolithiasis. The obtained data indicate the need to conduct a correlational analysis of risk factors in the group of patients with nephrolithiasis, in particular, the influence of the state of the bone system, the TBS indicator and crystalluria. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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