| Autor: |
Morán López, Jesús Manuel, Benítez Díaz, Mónica, León, María Piedra, Cordero Pearson, Andrea, Enciso Izquierdo, Fidel Jesús, Amado Señaris, José Antonio |
| Předmět: |
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| Zdroj: |
Journal of Osteoporosis & Mineral Metabolism / Revista de Osteoporosis y Metabolismo Mineral (English edition); ene-mar2024, Vol. 16 Issue 1, p24-27, 4p |
| Abstrakt: |
Introduction: we report the emergence of resistance to the action of teriparatide in a patient with postsurgical hypoparathyroidism under replacement therapy with this molecule, who initially showed an optimal response. Case report: description of a case report in which a patient with postsurgical hypoparathyroidism treated with teriparatide showed progressive decrease in its effectiveness, and resistance to the biosimilar teriparatide with which the patient was treated was tested. The Ellsworth-Howard test was used to evaluate teriparatide resistance. Discussion: the patient showed a response to the Ellsworth-Howard test consistent with resistance to teriparatide. A comparison was made with a patient with chronic hypoparathyroidism who underwent the same test with the same molecule, obtaining an appropriate functional response. The occurrence of primary failure to teriparatide replacement therapy in the context of chronic hypoparathyroidism is presented. Autoimmune etiology due to the development of blocking autoantibodies is the most likely hypothesis. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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