| Autor: |
Xin Fu, Zhengwei Hu, Wenjun Li, Liang Ma, Junyu Chen, Muyang Liu, Jie Liu, Shuhan Hu, Huachun Wang, Yunxiang Huang, Guo Tang, Bozhen Zhang, Xue Cai, Yuqi Wang, Lizhu Li, Jian Ma, Song-Hai Shi, Lan Yin, Hao Zhang, Xiaojian Li |
| Předmět: |
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| Zdroj: |
Proceedings of the National Academy of Sciences of the United States of America; 7/23/2024, Vol. 121 Issue 30, p1-8, 8p |
| Abstrakt: |
The development of advanced neural modulation techniques is crucial to neuroscience research and neuroengineering applications. Recently, optical-based, nongenetic modulation approaches have been actively investigated to remotely interrogate the nervous system with high precision. Here, we show that a thin-film, silicon (Si)-based diode device is capable to bidirectionally regulate in vitro and in vivo neural activities upon adjusted illumination. When exposed to high-power and short-pulsed light, the Si diode generates photothermal effects, evoking neuron depolarization and enhancing intracellular calcium dynamics. Conversely, low-power and long-pulsed light on the Si diode hyperpolarizes neurons and reduces calcium activities. Furthermore, the Si diode film mounted on the brain of living mice can activate or suppress cortical activities under varied irradiation conditions. The presented material and device strategies reveal an innovated optoelectronic interface for precise neural modulations. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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