| Autor: |
Fiala, Gina J., Lücke, Jöran, Huber, Samuel |
| Předmět: |
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| Zdroj: |
European Journal of Immunology; Aug2024, Vol. 54 Issue 8, p1-9, 9p |
| Abstrakt: |
γδ T cells are a subset of T cells that are characterized by the expression of a TCR‐γδ instead of a TCR‐αβ. Despite being outnumbered by their αβ T cell counterpart in many tissues, studies from the last 20 years underline their important and non‐redundant roles in tumor and metastasis development. However, whether a γδ T cell exerts pro‐ or antitumorigenic effects seems to depend on a variety of factors, many of them still incompletely understood today. In this review, we summarize mechanisms by which γδ T cells exert these seemingly contradictory effector functions in mice and humans. Furthermore, we discuss the current view on inducing and inhibiting factors of γδ T cells during cancer development. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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