Secofumitremorgins C and D, a pair of atropisomers from saltern-derived fungus Aspergillus fumigatus GXIMD00544.

Autor: Zhang, Geng-Si, Li, Hai-Yan, Liang, Li-Fen, Fu, Chun-Qing, Yu, Qin, Liu, Kai, Su, Zhi-Wei, Zhou, Dong-Mei, Gao, Cheng-Hai, Xu, Xin-Ya, Liu, Yong-Hong
Předmět:
Zdroj: Journal of Asian Natural Products Research; Sep2024, Vol. 26 Issue 9, p1049-1056, 8p
Abstrakt: A pair of atropisomers secofumitremorgins C (1a) and D (1b), together with fifteen known alkaloids (2-16), were isolated from a saltern-derived fungus Aspergillus fumigatus GXIMD00544. The structures of atropisomers 1a and 1b were elucidated by the detailed spectroscopic data, chemical reaction and quantum chemical calculations. Compounds 1 and 8 displayed antifungal spore germination effects against plant pathogenic fungus associated with sugarcane Fusarium sp. with inhibitory rates of 53% and 77% at the concentration of 100 µM, repectively. Atropisomers 1 also exhibited antifouling potential against Balanus amphitrite larval settlement with an inhibitory rate of 96% at the concentration of 100 µM. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index