Improvement in Glycemic Indices and Point in Range by Addition or Switch to IDegAsp-Real-World Evidence.
| Autor: | Seshadri, Krishna G., Polisetti, Subhadra, Tippisetty, Surekha |
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| Předmět: |
GLYCOSYLATED hemoglobin
FOOD consumption T-test (Statistics) INSULIN derivatives GLYCEMIC control SCIENTIFIC observation RETROSPECTIVE studies HYPOGLYCEMIC agents DESCRIPTIVE statistics TREATMENT effectiveness INSULIN aspart BLOOD sugar PRE-tests & post-tests TYPE 2 diabetes DRUG efficacy GLYCEMIC index GENERIC drug substitution CONFIDENCE intervals EVALUATION |
| Zdroj: | Journal of Diabetology: Official Journal of Diabetes in Asia Study Group; Jul-Sep2024, Vol. 15 Issue 3, p286-290, 5p |
| Abstrakt: | Aim and Objectives: This study aimed to evaluate the effectiveness of insulin degludec/insulin aspart (IDegAsp) in uncontrolled type 2 diabetes mellitus (T2DM) patients in clinical practice settings. Materials and Methods: This study includes a retrospective analysis of uncontrolled T2DM patients on oral antidiabetic drugs and/or insulin (basal, bolus, or premix) and initiated on IDegAsp and in a subgroup of patients who switched from insulin glargine to IDegAsp. Clinical endpoints were mean change in glycated hemoglobin (HbA1c), fasting plasma glucose (FPG), postprandial plasma glucose (PPG), and % point in range (PIR) before and after treatment with IDegAsp. Descriptive statistics were applied to analyze the data, and statistical significance was set at P = 0.05. Results: A total of 540 patients with T2DM were initiated on IDegAsp, among which 85 switched from insulin glargine (U100/300) to IDegAsp. In 6 months, overall, the mean change in glycemic variables HbA1c, FPG, and PPG was -0.3%, -21 mg/dL, and -36 mg/dL, and among those who switched from insulin glargine to IDegAsp, it was -0.4%, -18 mg/dL, and -49 mg/dL, respectively, and the difference was statistically significant (P < 0.05). Self-monitored blood glucose, 1 month before and from 4 to 6 months after initiation of IDegAsp was assessed in overall 43 patients. The % PIR before breakfast and before dinner (BBF+BD) was 68% and 69% (95% CI -4.413 to 4.902) respectively. Furthermore, among those who switched from insulin glargine to IDegAsp (n = 25), BBF + BD increased from 67% to 77% (95% CI -10.35 to 10.65). Conclusion: Our results show clinically significant improvements in glycemic variables and PIR in patients treated with IDegAsp and especially in patients who switched from insulin glargine (U100/300) to IDegAsp. [ABSTRACT FROM AUTHOR] |
| Databáze: | Complementary Index |
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