تأثیر هشت هفته تمرینات تناوبی شنا با شدت بالا بر فاکتور نکروز دهنده تومور آلفا و فاکتور رشد تغییر دهنده بتا یک در بافت کبد موشهای صحرایی تغذیه شده با غذای پرچرب.
| Autor: | اکرم جوکار, هما شیخانی شاهین, مهرزاد مقدسی, علیرضا جوهری |
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| Předmět: |
TISSUE analysis
LIVER analysis NON-alcoholic fatty liver disease EXERCISE physiology DATA analysis HIGH-intensity interval training DIETARY fats EXERCISE intensity DESCRIPTIVE statistics RATS SWIMMING ANIMAL experimentation ONE-way analysis of variance STATISTICS INFLAMMATION TUMOR necrosis factors TRANSFORMING growth factors-beta BLOOD |
| Zdroj: | Arak Medical University Journal; Dec2023, Vol. 26 Issue 5, p9-19, 11p |
| Abstrakt: | Introduction: On average, patients suffering from non-alcoholic steatohepatitis after about seven years, their disease turns into fibrosis and reversibility at this stage becomes very difficult because this disease is an irreversible stage of the disease. Therefore, the effect of eight weeks of high-intensity interval training in water on inflammatory factors in patients with nonalcoholic steatohepatitis was investigated. Methods: In this study, eight-week-old male Sprague-Dawley rats were divided into healthy (n=20) and high-fat diet (HFD) (n=20) groups. After eight weeks and proof of disease induction, the HFD group was randomly divided into two groups: control-disease (n=9) and exercisedisease (n=9); Also, the healthy group was divided into two groups: control-healthy (n=9) and exercise-healthy (n=9). The rats in the training group performed HIIT swimming training, including 20 times of 30 seconds of swimming with 30 seconds of rest between each time, for eight weeks (three days a week). One-way ANOVA and Bonferroni's post hoc test (P<0.05) were used to determine the difference between groups. The proposal of this study has been approved by the Ethics Committee of Shiraz University of Medical Sciences (IR.SUMS.REHAB.REC.1400.008). Results: As shown in diagram 1; Based on the results of the one-way analysis of variance test, it can be said that there was a significant difference between the mean TNF-α blood serum (P=0.001). According to the results of Bonferroni's post hoc test, there was a significant increase in the patient-control group compared to the healthy-control group (P=0.001) and also a significant decrease in the patient-exercise group compared to the patient-control group (P=0.012). Also, a significant decrease was observed in the exercise-healthy group compared to the control-patient group (P=0.001) and the exercise-patient group (P=0.002). Conclusions: The results of the present research showed that high-intensity intermittent swimming exercises reduce inflammatory and fibrotic factors, and in general, it can be concluded that eight weeks of high-intensity intermittent swimming exercises improve the inflammatory and fibrotic factors associated with non-alcoholic steatohepatitis. . However, to obtain a definitive result, this type of exercise should be studied in human studies in this patient community. [ABSTRACT FROM AUTHOR] |
| Databáze: | Complementary Index |
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