A chalcone derivative SBD-2 exerts anticancer effects in human colorectal cancer cells.

Autor:	Zheng, Bowen, Lin, Wanjun, Zhang, Na, Huang, Xiaoming, Du, Jingjing, Shen, Yunfu, Chen, Junhe, Lin, Qianyu, Yang, Zhuya, Ma, Wenzhe
Předmět:	CHINESE medicine COLORECTAL cancer CHALCONE INHIBITION of cellular proliferation CELL cycle
Zdroj:	Future Journal of Pharmaceutical Sciences; 8/6/2024, Vol. 10 Issue 1, p1-9, 9p
Abstrakt:	Background: In this study, the potential anticancer activity and mechanism of action of SBD-2, a chalcone isolated from Shuteria involucrata, was investigated in colorectal cancer (CRC) cells. Results: SBD-2 inhibited the proliferation of Caco-2 cells in a dose-dependent manner. It elicited the cells arrested in the G2/M phase and induced apoptosis. Mechanistically, SBD-2 inhibited Akt phosphorylation, which suppressed the ani-apoptotic protein Bcl-2 and cell cycle regulator Cyclin B1, leading to apoptosis ad cycle arrest, respectively. Conclusions: The presented chalcone compound SBD-2 from Shuteria involucrata induced apoptosis and cell cycle arrest through inhibiting Akt pathway, highlighting the possibility to develop as a new agent for CRC treatment. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
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