Two-dimensional and three-dimensional oxygen mapping by 3He-MRI validation in a lung phantom.
| Autor: | Gast, Klaus, Schreiber, Wolfgang, Herweling, Annette, Lehmann, Frank, Erdös, Gabor, Schmiedeskamp, Joerg, Kauczor, Hans-Ulrich, Eberle, Balthasar, Gast, Klaus Kurt, Schreiber, Wolfgang G, Erdös, Gabor |
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| Předmět: |
RESPIRATORY gas monitoring
PULMONARY function tests MEDICAL imaging systems IMAGING phantoms MEDICAL radiology MEDICAL research COMPARATIVE studies HELIUM DIGITAL image processing ISOTOPES LUNGS MAGNETIC resonance imaging RESEARCH methodology MEDICAL cooperation OXYGEN RESEARCH RESPIRATION THREE-dimensional imaging EVALUATION research OXYGEN consumption PARTIAL pressure |
| Zdroj: | European Radiology; Sep2005, Vol. 15 Issue 9, p1915-1922, 8p |
| Abstrakt: | The aim of this study was to validate oxygen-sensitive 3He-MRI in noninvasive determination of the regional, two- and three-dimensional distribution of oxygen partial pressure. In a gas-filled elastic silicon ventilation bag used as a lung phantom, oxygen sensitive two- and three-dimensional 3He-MRI measurements were performed at different oxygen concentrations which had been equilibrated in a range of normal and pathologic values. The oxygen partial pressure distribution was determined from 3He-MRI using newly developed software allowing for mapping of oxygen partial pressure. The reference bulk oxygen partial pressure inside the phantom was measured by conventional respiratory gas analysis. In two-dimensional measurements, image-based and gas-analysis results correlated with r=0.98; in three-dimensional measurements the between-methods correlation coefficient was r=0.89. The signal-to-noise ratio of three-dimensional measurements was about half of that of two-dimensional measurements and became critical (below 3) in some data sets. Oxygen-sensitive 3He-MRI allows for noninvasive determination of the two- and three-dimensional distribution of oxygen partial pressure in gas-filled airspaces. [ABSTRACT FROM AUTHOR] |
| Databáze: | Complementary Index |
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