Decision Making in Predicting the Dynamics of Viral Infection Considering Diffusion-Convective Migration of Active Factors Via Several Ways Under Immunotherapy.

Autor: Baranovsky, S. V., Bomba, A. Ya.
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Zdroj: Cybernetics & Systems Analysis; Jul2024, Vol. 60 Issue 4, p561-570, 10p
Abstrakt: The authors modified a mathematical model of infectious disease to account for the influence of various migration ways of active factors within the internal environment of the human body, considering the complexity of distinguishing different conditions for the spread of antigens, antibodies, and medicinal substances in the intercellular space and lymphatic system when predicting the dynamics of a viral infection. They obtained the solution to the model singularly perturbed problem with a delay based on the adapted computational technology. This technology provides a step-by-step numerical-asymptotic approximation of a specially constructed sequence of problems without delay as perturbations of the solutions to the corresponding degenerate problems. The presented results of computer modeling illustrate the predicted contribution of several migration ways of active factors in developing an infectious disease. Note that the effectiveness of immunologic agents, among other things, will also be influenced by conditions determined by the migration way of donor antibodies in the body environment. One should consider this influence in decision-making systems for elaborating appropriate rational treatment programs. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index
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