| Autor: |
Houlder, Emma L., Stam, Koen A., Koopman, Jan Pieter R., König, Marion H., Langenberg, Marijke C. C., Hoogerwerf, Marie-Astrid, Niewold, Paula, Sonnet, Friederike, Janse, Jacqueline J., Partal, Miriam Casacuberta, Sijtsma, Jeroen C., de Bes-Roeleveld, Laura H. M., Kruize, Yvonne C. M., Yazdanbakhsh, Maria, Roestenberg, Meta |
| Předmět: |
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| Zdroj: |
Science Immunology; Jul2024, Vol. 9 Issue 97, p1-13, 13p |
| Abstrakt: |
Schistosomiasis is an infection caused by contact with Schistosoma-contaminated water and affects more than 230 million people worldwide with varying morbidity. The roles of T helper 2 (TH2) cells and regulatory immune responses in chronic infection are well documented, but less is known about human immune responses during acute infection. Here, we comprehensively map immune responses during controlled human Schistosoma mansoni infection using male or female cercariae. Immune responses to male or female parasite single-sex infection were comparable. An early TH1-biased inflammatory response was observed at week 4 after infection, which was particularly apparent in individuals experiencing symptoms of acute schistosomiasis. By week 8 after infection, inflammatory responses were followed by an expansion of TH2 and regulatory cell subsets. This study demonstrates the shift from TH1 to both TH2 and regulatory responses, typical of chronic schistosomiasis, in the absence of egg production and provides immunological insight into the clinical manifestations of acute schistosomiasis. Editor's summary: Schistosomiasis infection causes more than 230 million infections worldwide, but immune responses during acute infection are not well understood. To better observe these responses, Houlder et al. used controlled human Schistosoma mansoni infections with either male or female cercaria-stage parasites. T helper 1 (TH1) cell–biased inflammatory responses dominated at early time points (4 weeks after infection), and male and female parasites induced similar responses. At 8 weeks after infection, TH2 and regulatory cell responses were more dominant and were consistent with responses seen during chronic infection. These results highlight the shift in immune responses occurring over the course of infection. —Christiana Fogg [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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