| Autor: |
Mahfoudhi, Amira, Ben Mabrouk, Sameh, Hadrich, Bilel, Mhadhbi, Mohsen, Abderrazak, Houyem, Alghamdi, Othman A., Fendri, Ahmed, Sayari, Adel |
| Předmět: |
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| Zdroj: |
Catalysis Letters; Aug2024, Vol. 154 Issue 8, p4283-4301, 19p |
| Abstrakt: |
Driven by the increasing demand for novel lipophilic antioxidants for emulsions and oil-based formulas, a non-commercial immobilized Rhizopus oryzae lipase's capacity to catalyze butanol, octanol, and dodecanol esterification with piperic acid was optimized using Response Surface Methodology. The optimized conversion yield (92.21 ± 4.53%) for the synthesis of butyryl piperate was obtained by using 300 IU of immobilized lipase, with piperic acid/butanol substrate molar ratio of 1/8 in 3.6 mL of dichloromethane. The reaction was conducted at 30°C at 50 rpm for 48 h. Moreover, the two other esters (octyl- and dodecyl-piperate), which were synthesized using the same optimal conditions, appeared stable. The kinetic studies that the lowest KM app. (30 mM) and the highest Vmax (0.055 ± 0.003 µmol/h) were obtained for octyl-piperate synthesis showing that the immobilized lipase's affinity leaned more to octanol compared to the other fatty alcohols. FTIR results of the obtained esters show the band emerging at 1712 cm−1, 1723 cm−1, and 1753 cm−1 corresponding to the presence of the ester group bands of Butyryl piperate, Octyl piperate, and Dodecyl piperate, respectively. The esterification was also confirmed by the determination of the three esters' molecular masses using ICP-MS. Finally, the antioxidant ability of these newly created esters was approved, showing that the octyl-piperate presents the highest antioxidant activity. The novel lipophilic antioxidant compounds obtained by a green process could be potential candidates, especially in food-, cosmetic- and pharmaceutical-based emulsion preservation. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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