| Abstrakt: |
Introduction: Sthaulyahara Ghana Vati (SHGV) is a polyherbal formulation, which is indicated in Sthualya (obesity) in Vaidhyasara sangraha. There are few clinical works carried out on this medicine, but no any researchers had evaluated this formulation for its quality control (QC) parameters. Pharmacopeia standards for this formulation are also not available till date. Aim: To evaluate SHGV through pharmacognostical, physiochemical parameters and high-performance thin-layer chromatography (HPTLC) fingerprinting. Materials and Methods: Preauthenticated raw drugs of SHGV were procured, and SHGV was prepared at pharmacy, Institute of Teaching and Research in Ayurveda (ITRA), Jamnagar. Organoleptic parameters and microscopic analysis of SHGV were carried out at the Pharmacognosy Department, ITRA, Jamnagar. Physiochemical analysis and HPTLC of SHGV were carried out at the Pharmaceutical Laboratory, ITRA, Jamnagar. Result: Microscopic features of SHGV were cross-checked with Ayurvedic pharmacopeia of India standards of individual ingredients, and it was found to have characteristics of all ingredients in it. In pharmaceutical parameters, pH value was 6.0, water-soluble extract was 16.2% w/w, methanol-soluble extract was 14.9% w/w, ash value was 11.8% w/w, and loss on drying was 3.9% w/w. HPTLC at 254 and 366 nm showed six and three spots, respectively. Conclusion: This study has generated preliminary data on pharmacognostical, pharmaceutical parameters, and HPTLC. This fingerprinting can be useful for future researchers to reproduce this formulation and to establish QC parameter of SHGV. [ABSTRACT FROM AUTHOR] |
