| Autor: |
Fuld, Sybille, Constantinescu, Georgiana, Pamporaki, Christina, Peitzsch, Mirko, Schulze, Manuel, Jun Yang, Müller, Lisa, Prejbisz, Aleksander, Januszewicz, Andrzej, Remde, Hanna, Kürzinger, Lydia, Dischinger, Ulrich, Ernst, Matthias, Gruber, Sven, Reincke, Martin, Beuschlein, Felix, Lenders, Jacques W. M., Eisenhofer, Graeme |
| Předmět: |
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| Zdroj: |
Journal of Applied Laboratory Medicine; Jul2024, Vol. 9 Issue 4, p752-766, 15p |
| Abstrakt: |
Background: Measurements of aldosterone by mass spectrometry are more accurate and less prone to interferences than immunoassay measurements, and may produce a more accurate aldosterone:renin ratio (ARR) when screening for primary aldosteronism (PA). Methods: Differences in diagnostic performance of the ARR using mass spectrometry vs immunoassay measurements of aldosterone were examined in 710 patients screened for PA. PA was confirmed in 153 patients and excluded in 451 others. Disease classifications were not achieved in 106 patients. Areas under receiver-operating characteristic curves (AUROC) and other measures were used to compare diagnostic performance. Results: Mass spectrometry-based measurements yielded lower plasma aldosterone concentrations than immunoassay measurements. For the ARR based on immunoassay measurements of aldosterone, AUROCs were slightly lower (P = 0.018) than those using mass spectrometry measurements (0.895 vs 0.906). The cutoff for the ARR to reach a sensitivity of 95% was 30 and 21.5 pmol/mU by respective immunoassay and mass spectrometry-based measurements, which corresponded to specificities of 57% for both. With data restricted to patients with unilateral PA, diagnostic sensitivities of 94% with specificities >81% could be achieved at cutoffs of 68 and 52 pmol/mU for respective immunoassay and mass spectrometry measurements. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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