| Autor: |
Sagun, Kumari, Vanlalmalsawmropuia, H., Roy, Vikas Kumar, Gurusubramanian, Guruswami |
| Předmět: |
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| Zdroj: |
Journal of Experimental Zoology India; Jul2024, Vol. 27 Issue 2, p2331-2336, 6p |
| Abstrakt: |
Garcinia lanceifolia, also locally referred to as "Pelh" (Mizo), is a significant and endemic medicinal edible fruit tree found in North East India. The aim of this study was to evaluate the anti-ulcer properties of a methanolic extract of G. lanceifolia fruit (GLME) against ethanol-induced gastric tissue damage in rats. Adult Wistar albino rats were given oral pretreatment doses of GLME (400 and 600 mg/kg of GLME in CMC solution) one hour before oral administration of absolute ethanol to assess their gastric mucosal injury protective properties. The control group received only carboxymethyl cellulose (CMC), the ulcer control group received absolute ethanol (5 ml/kg) and the positive reference group received the anti-ulcer drug omeprazole 20 mg/kg. The GLME pre-treatment group (400 mg/kg) exhibited a significant decrease in gastric mucosal injury, as demonstrated by histological investigations and showed marked gastric mucosal protection, reduction or absence of lesions, and infiltration injury of the submucosal layer. Conversely, the ulcer control group showed severe damage to the gastric mucosa lining. There is a significant increase in pH and a decrease in the total acidity in GLME-pretreated rats compared to the ulcer control group (p<0.001). Further, there is significant percentage inhibition and decreased ulcer index at 400 mg/kg pre-treated dose compared to the the ulcer control group (p<0.001). Thus, in comparison to the ulcer control group, the current finding suggests that the methanolic extract of G. lanceifolia fruit rind extract has anti-ulcerogenic potential. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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