| Abstrakt: |
The present study investigated the effect of Aceclofenac, a non-steroidal anti-inflammatory drug (NSAID), on the physiology of T. trichopterus (three-spot gourami) as an animal model. Aceclofenac is known for its analgesic and antiinflammatory properties, but its use can lead to severe effects. The study aimed to assess the toxicity of aceclofenac by examining histological changes in the gills and liver, as well as analysing liver marker enzymes in T. trichopterus. The experiment involved a 15-day exposure of disease-free T. trichopterus to a concentration of 0.1 mg aceclofenac/L, while the control group remained untreated. The results demonstrated a significant increase in AspAT and AlaAT activity in fish exposed to aceclofenac compared to the control group. Histopathological examinations revealed necrosis and slight degeneration of gill filaments, as well as hepatocellular degeneration, necrosis, sinusoidal dilatation and cytoplasmic vacuolation in the liver sections of the experimental group. In conclusion, exposure to aceclofenac caused histological alterations in the gills and liver of T. trichopterus, along with elevated AspAT and AlaAT activities, indicating potential liver damage. These findings underscore the potential health risks associated with Aceclofenac use in humans due to Aceclofenac and its metabolites, as well as promoting safe drug use, educating patients about potential risks and implementing regulatory measures that emphasize medical consultation and adherence to prescribed dosages, safeguarding individuals from potential harm, while maximizing the medication's therapeutic benefits. [ABSTRACT FROM AUTHOR] |
