| Autor: |
Kumar, Sunil, Sindhu, Rakesh Kumar |
| Předmět: |
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| Zdroj: |
Journal of Experimental Zoology India; Jul2024, Vol. 27 Issue 2, p1721-1724, 4p |
| Abstrakt: |
Sodium butyrate used to increase the glutathione redox system and diminished the oxidative stress. It inhibits proliferation, induction of differentiation and induction or repression of gene expression and it has also anti-inflammatory action. This is endorsed for suppression of nephrotic symptoms. The pharmacological prospective was estimated in gentamicininduced rats through the oral administration of Sodium Butyrate formulation 200mg/kg and 300mg/kg BW. The study observed that the Sodium Butyrate significantly protect the kidneys from Gentamicin-induced nephrotic disorders. Gentamicin 100 mg/kg for seven day was used for induction of nephrotoxicity in Wistar rat by intraperitoneal administration. The administration of SB was observed to decrease the occurrence of glomerular congestion, vascular congestion, epithelial desquamation, inflammatory cell build-up and kidney cell necrosis induced by Gentamicin. Dose of SB maintained the Gentamicininduced altered MDA (7.330±0.781), GSH (21.252±1.970), CAT (11.263±1.092), SOD (902.778±72.783) & NO (174.704±7.283) levels. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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