MICROFLUIDICS IN DRUG DISCOVERY: ADVANCEMENTS, APPLICATIONS AND FUTURE PERSPECTIVES- A REVIEW.

Autor: Vinay, P. J., Sankula, Kameswara Rao, Dudekula, Jamal Basha, Kar, Sanjeeb Kumar, Gupta, Niraj, Burman, Varsha, Pamu, Sagar, DeviPamu, Dasari Vasavi, Devl, Dasari Vasavi
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Zdroj: Journal of Experimental Zoology India; Jul2024, Vol. 27 Issue 2, p1527-1537, 11p
Abstrakt: Microfluidics, a multidisciplinary field at the intersection of physics, engineering and biology is reshaping drug discovery. This review delves into its historical evolution, fundamental principles, components and manufacturing techniques. Microfluidics operates with precision, offering laminar flow, efficient mass transfer and scaling laws. Platforms like microscale cell culture systems, high-throughput screening techniques, lab-on-a-chip devices and organ-on-a-chip systems are driving advancements in disease modeling and pharmacokinetics. Despite challenges in device fabrication, regulation and costs, microfluidics promises an efficient, patient-centric future for drug discovery. Collaborative innovation can unlock its potential, making drug development faster, more precise and accessible. Microfluidics stands as a transformative force with the potential to revolutionize the drug development process. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index