| Autor: |
Zhou, Chen, Dai, Mengfu, Yin, Xiaoyu, Zhang, Mingyue, Gu, Weijin, Chen, Liang‐An |
| Zdroj: |
Chinese Journal of Chemistry; Sep2024, Vol. 42 Issue 17, p1993-1998, 6p |
| Abstrakt: |
Comprehensive Summary: The stereochemical synthesis of highly substituted Danishefsky‐type dienes remains unsolved in organic chemistry. We describe a simple and efficient approach for the stereoselective synthesis of Danishefsky‐type trisubstituted dienes from readily available propargylic esters via Pd‐catalyzed dienylation reaction through the key intermediate metallacyclobutene in a regio‐, chemo‐ and stereoselective fashion. This method facilitates a broad range of challenging trisubstituted dienes with a high level of stereocontrol. The synthetic utilities of oxygenated trisubstituted dienes have been demonstrated by the downstream chemistry, which notably undergoes Diels‐Alder reaction with a variety of electron‐deficient dienophiles to furnish multisubstituted cyclohexenes in good yields with excellent stereoselectivity. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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