Dual-systems models of the genetic architecture of impulsive personality traits: neurogenetic evidence of distinct but related factors.
Autor: | Miller, Alex P., Gizer, Ian R. |
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Předmět: |
PERSONALITY & genetics
RISK assessment BIOLOGICAL models EMOTION regulation RESEARCH funding GENOME-wide association studies RISK-taking behavior STRUCTURAL equation modeling IMPULSIVE personality NEUROLOGICAL disorders GRAY matter (Nerve tissue) NEURORADIOLOGY BRAIN cortical thickness GENETICS PHENOTYPES GENOMES DISEASE risk factors PHYSIOLOGY |
Zdroj: | Psychological Medicine; Jun2024, Vol. 54 Issue 8, p1533-1543, 11p |
Abstrakt: | Background: Dual-systems models, positing an interaction between two distinct and competing systems (i.e. top-down self-control, and bottom-up reward- or emotion-based drive), provide a parsimonious framework for investigating the interplay between cortical and subcortical brain regions relevant to impulsive personality traits (IPTs) and their associations with psychopathology. Despite recent developments in multivariate analysis of genome-wide association studies (GWAS), molecular genetic investigations of these models have not been conducted. Methods: Using IPT GWAS, we conducted confirmatory genomic structural equation models (GenomicSEM) to empirically evaluate dual-systems models of the genetic architecture of IPTs. Genetic correlations between dual-systems factors and relevant cortical and subcortical neuroimaging phenotypes (regional/structural volume, cortical surface area, cortical thickness) were estimated and compared. Results: GenomicSEM dual-systems models underscored important sources of shared and unique genetic variance between top-down and bottom-up constructs. Specifically, a dual-systems genomic model consisting of sensation seeking and lack of self-control factors demonstrated distinct but related sources of genetic influences (r |
Databáze: | Complementary Index |
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