| Autor: |
Esposito, Silvano, Pagliano, Pasquale, De Simone, Giuseppe, Guarino, Amedeo, Pan, Angelo, Brambilla, Paola, Mastroianni, Claudio, Lichtner, Miriam, Brugnaro, Pierluigi, Carretta, Anna, Santantonio, Teresa, Brindicci, Gaetano, Carrega, Giuliana, Montagnani, Francesca, Lapadula, Giuseppe, Spolti, Anna, Luzzati, Roberto, Schiaroli, Elisabetta, Scaglione, Vittoria, Pallotto, Carlo |
| Předmět: |
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| Zdroj: |
Infection; Aug2024, Vol. 52 Issue 4, p1297-1306, 10p |
| Abstrakt: |
Purpose: Although dalbavancin is currently approved for the treatment of ABSSIs, several studies suggest its efficacy and tolerance as long-term therapy for other off-label indications requiring prolonged intravenous antibiotic administration. Methods: We conducted a prospective nationwide study of dalbavancin use in real-life settings for both approved and off-label indications analysing for each case the clinical and microbiological characteristics of infection the efficacy and safety of treatments. Results: During the study period (from December 2018 to July 2021), the ID specialists from 14 different centres enrolled 223 patients treated with dalbavancin [141 males (63%) and 82 females (37%); male/female ratio 1.72; mean age 59 (SD 17.2) years, (range 15–96). Most patients in the study population (136/223; 61.0%) came from community rather than health care facilities and most of them were visited in Infectious Diseases wards (93/223; 41.7%) and clinics (55/223; 24.7%) even though some patients were cured in other settings, such as surgery wards (18/223; 8.1%), orthopaedic wards (11/223; 4.9%), Emergency Rooms (7/223; 3.1%) and non-surgical other than ID wards (6/223; 2.7%). The most common ID diagnoses were osteomyelitis (44 cases/223; 19.7%; of which 29 acute and 15 chronic osteomyelitis), cellulitis (28/223; 12.5%), cutaneous abscess (23/223; 10.3%), orthopaedic prosthesis-associated infection (22/223; 9.9%), surgical site infection (20/223; 9.0%) and septic arthritis (15/223; 6.7%). Conclusion: In conclusion, by virtue of its PK/PD properties, dalbavancin represents a valuable option to daily in-hospital intravenous or outpatient antimicrobial regimens also for off-label indications requiring a long-term treatment of Gram-positive infections. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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