Comparable long-term survival outcomes after endoscopic and gastrectomy treatment of pT1acN0M0 gastric adenocarcinoma in patients who met the expanded criteria.
| Autor: | JingRu, Chen, GuoHui, Mei, LiLi, Guo, ZhenYu, Chang, MingHua, Zhu, ZeLong, Yang, ChunXi, Wang |
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| Předmět: |
ADENOCARCINOMA
GASTRECTOMY STOMACH tumors DIGESTIVE system endoscopic surgery SURVIVAL rate DECISION making in clinical medicine DESCRIPTIVE statistics RETROSPECTIVE studies CHI-squared test LONGITUDINAL method KAPLAN-Meier estimator LOG-rank test MEDICAL records ACQUISITION of data SURVIVAL analysis (Biometry) CONFIDENCE intervals DATA analysis software PROPORTIONAL hazards models |
| Zdroj: | Surgical Endoscopy & Other Interventional Techniques; Aug2024, Vol. 38 Issue 8, p4215-4221, 7p |
| Abstrakt: | Background: Whether the Western pT1acN0M0 gastric cancer (GC) patients who met the Japanese expanded criteria could be the candidates for endoscopic treatment (ET) remains unclear because of unknown long-term survival outcomes. Methods: A retrospective cohort study using data from the Surveillance, Epidemiology, and End Results (SEER) program was performed. The survival differences between pT1acN0M0 gastric adenocarcinoma patients who received ET or gastrectomy treatment (GT) were evaluated using multivariate survival analysis. Results: A total of 314 pT1acN0M0 gastric adenocarcinoma patients who met the expanded criteria were included, 46 patients received ET and 268 patients received GT. pT1acN0M0 gastric adenocarcinoma patients met the expanded criteria underwent ET experienced a similar hazard of cancer-specific death compared with those underwent GT both in the multivariate Cox survival analysis (adjusted hazard ratio [HR]; 1.18, 95% confidence interval [CI] 0.40–3.49; P = 0.766) and the multivariate competing risk model (subdistribution HR [SHR], 1.12, 95% CI 0.38–3.29; P = 0.845). The result that pT1acN0M0 gastric adenocarcinoma patients met the expanded criteria underwent ET experienced comparable survival outcomes to those who underwent GT did not change even compared with those who underwent GT with > 15 lymph nodes examined (adjusted HR, 1.55, 95% CI 0.44–5.49; P = 0.499; SHR, 1.47, 95% CI 0.44–4.88; P = 0.532). Conclusions: The ET can be considered in Western pT1acN0M0 gastric adenocarcinoma patients who met the Japanese expanded criteria. However, a prospective study should be warranted. [ABSTRACT FROM AUTHOR] |
| Databáze: | Complementary Index |
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