| Autor: |
Vinila, B. H. Shiny, Vishali, N., Gannepalli, Ashalata, Teja, N. Soukya |
| Zdroj: |
Pravara Medical Review; Jun2024, Vol. 16 Issue 2, p5-9, 5p |
| Abstrakt: |
Background: Tinospora Cordifolia satva is an ayurvedic preparation from the stem of Tinospora Cordifolia and commonly used in ayurvedic medicine to treat various diseases. The anticancer activity of the Tinospora Cordifolia satva was not well reported in the literature. Thus, the present stud y was aimed to find the anticancer activity of Tinospora Cordifolia satva on oral squamous cell carcinoma cell line. Materials and methods: The Human oral squamous cell carcinoma cell line OECM-1 was procured from Sigma Aldrich and Tinospora Cordifolia satva was procured from standard ayurvedic pharmacy. MTT assay was performed treating the cells with 12.5, 25, 50, 75, 100 and 200 µg/ml concentrations of Tinospora Cordifolia satva. The absorbance was read on a spectrophotometer at 570nm wavelength and the values were recorded, cell viability was calculated and the IC50 value was determined. Results: Tinospora Cordifolia satva had effectively inhibited cell proliferation in a dose dependent manner. The least dose 12.5 µg/ml also showed antiproliferative activity with the IC50 value of 148 µg/ml. Conclusion: Tinospora Cordifolia satva had inhibited cell proliferation effectively in dose dependent pattern. Thus, it can be included in the treatment of oral squamous cell carcinoma. Further, clinical trials can be carried out to fix the optimum dose as it is inhibiting cell proliferation in OSCC cell line with the lowest dose. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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