Antiphospholipid antibodies in patients hospitalized with COVID-19 infection in conventional units.
| Autor: | Razaghi, Mahta, Mohammadi, Farshid, Hoseinzadeh, Edris, Roshanaei, Ghodratollah, Najafi, Sara Zangene |
|---|---|
| Předmět: |
ANTICOAGULANTS
STATISTICAL correlation RESEARCH funding T-test (Statistics) AUTOANTIBODIES ENZYME-linked immunosorbent assay VEINS GLYCOPROTEINS MANN Whitney U Test DESCRIPTIVE statistics CASE-control method RESEARCH THROMBOEMBOLISM COMPARATIVE studies DATA analysis software ANTIPHOSPHOLIPID syndrome COVID-19 HOSPITAL wards |
| Zdroj: | International Archives of Health Sciences; Feb2024, Vol. 11 Issue 1, p56-61, 6p |
| Abstrakt: | Objectives: This study aimed to evaluate the status of antiphospholipid antibodies (APL) in hospitalized patients with COVID-19 infection. Methods: This case-control study was conducted at Shahid Beheshti Hospital of Hamadan University of Medical Sciences from 2020 to 2022. Participants were divided into two groups; COVID-19 (n=35 recovered cases) and non-COVID-19 (n=34). The study assessed anticardiolipin antibodies (ACA) including IgM, IgG, and antibodies against ß2-glycoprotein (anti-B2GPI). Additionally, the lupus anticoagulant (LAC) test was conducted on patients not using anticoagulant medications. Enzyme-linked immunosorbent assay (ELISA) was employed for ACA and anti-B2GPI testing, while the LAC test was conducted using a fully automated coagulometer. Results: The mean LAC among participants was 33.8 ± 7.53s for females and 36.39 ± 5.54s for males. Results of antibody tests indicated that ACA IgM was positive in 2 out of 33 cases, with none in the non-recovered COVID-19 and COVID-19 patients (P value = 0.15). Furthermore, the LAC test showed positive results in 5 and 2 patients in the case and control groups, respectively (P value = 0.26). Correlation analyses of LAC with other antibodies revealed no significant associations for non-COVID-19 patients, while a significant association was observed between LAC and ß2GPI IgG and ACA IgG (r = 0.52; P <0.001 and r = 0.51; P <0.001, respectively). Negative correlations were found between LAC and ACA IgM and hospitalization in the case group (r = -0.22 and r = -0.04, respectively). For the control group, negative correlations were observed between LAC and ß2GPI IgM, ACA IgG, and ACA IgM (r = -0.25, r = -0.03, and r = -0.03, respectively). Additionally, Anti-ß2GPI IgG and anti-ß2GPI IgM tests were positive in both COVID-19 and non-COVID-19 groups (two positives in total) (P value = 0.98 vs P value = 0.31). Conclusion: We recommend routine testing for aPL antibodies in recovered COVID-19 patients to assess their normal condition. Our findings suggest that APS antibodies in COVID-19 patients can serve as a negative prognostic indicator, guiding decisions on the need for intensive care based on antibody levels. [ABSTRACT FROM AUTHOR] |
| Databáze: | Complementary Index |
| Externí odkaz: |
|