Association of modified dementia risk score with cerebrospinal fluid biomarkers and cognition in adults without dementia.
Autor: | Qiong-Yao Li, Yan Fu, Xin-Jing Cui, Zuo-Teng Wang, Lan Tan |
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Předmět: |
DEMENTIA risk factors
RISK assessment ALZHEIMER'S disease RECEIVER operating characteristic curves RESEARCH funding PROBABILITY theory QUESTIONNAIRES NEUROINFLAMMATION DESCRIPTIVE statistics LONGITUDINAL method GERIATRIC Depression Scale FACTOR analysis CONFIDENCE intervals DATA analysis software COGNITION BIOMARKERS REGRESSION analysis ADULTS |
Zdroj: | Frontiers in Aging Neuroscience; 2024, p1-13, 13p |
Abstrakt: | Introduction: This study aimed to investigate the cognitive profile and prospective cognitive changes in non-demented adults with elevated Modified Dementia Risk Scores (MDRS), while also exploring the potential relationship between these associations and cerebrospinal fluid (CSF) biomarkers of Alzheimer's disease (AD) pathology and neuroinflammation. Methods: Within the Chinese Alzheimer's Biomarker and LifestylE (CABLE) database, 994 participants without dementia were assessed on MDRS, CSF biomarkers and cognition. We examined the associations of the MDRS with CSF biomarkers and cognitive scores using linear regressions. Causal mediation analyses were conducted to analyze the associations among MDRS, brain pathologies, and cognition. The Alzheimer's Disease Neuroimaging Initiative (ADNI) study was used to validate the mediation effects and to investigate the longitudinal association between MDRS and cognitive decline. Results: The results revealed that higher MDRS were linked to poorer cognitive performance (Model 1: P |
Databáze: | Complementary Index |
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