| Autor: |
Teijlingen, Nienke H van, Smoorenburg, Marleen Y van, Sarrami-Forooshani, Ramin, Zijlstra-Willems, Esther M, Hamme, John L van, Borgdorff, Hanneke, Wijgert, Janneke H H M van de, Leeuwen, Elisabeth van, Post, Joris A M van der, Strijbis, Karin, Ribeiro, Carla M S, Geijtenbeek, Teunis B H |
| Předmět: |
|
| Zdroj: |
Journal of Infectious Diseases; 7/15/2024, Vol. 230 Issue 1, pe43-e47, 5p |
| Abstrakt: |
Dysbiosis of the vaginal microbiome poses a serious risk for sexual human immunodeficiency virus type 1 (HIV-1) transmission. Prevotella spp are abundant during vaginal dysbiosis and associated with enhanced HIV-1 susceptibility; however, underlying mechanisms remain unclear. Here, we investigated the direct effect of vaginal bacteria on HIV-1 susceptibility of vaginal CD4+ T cells. Notably, pre-exposure to Prevotella timonensis enhanced HIV-1 uptake by vaginal T cells, leading to increased viral fusion and enhanced virus production. Pre-exposure to antiretroviral inhibitors abolished P timonensis –enhanced infection. Our study shows that the vaginal microbiome directly affects mucosal CD4+ T-cell susceptibility, emphasizing importance of vaginal dysbiosis diagnosis and treatment. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
|
