| Autor: |
Tehrani, Zahra R, Habibzadeh, Parham, Flinko, Robin, Chen, Hegang, Abbasi, Abdolrahim, Yared, Jean A, Ciupe, Stanca M, Lewis, George K, Sajadi, Mohammad M |
| Předmět: |
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| Zdroj: |
Journal of Infectious Diseases; 7/15/2024, Vol. 230 Issue 1, pe30-e33, 4p |
| Abstrakt: |
Generation of a stable long-lived plasma cell (LLPC) population is the sine qua non of durable antibody responses after vaccination or infection. We studied 20 individuals with a prior coronavirus disease 2019 infection and characterized the antibody response using bone marrow aspiration and plasma samples. We noted deficient generation of spike-specific LLPCs in the bone marrow after severe acute respiratory syndrome coronavirus 2 infection. Furthermore, while the regression model explained 98% of the observed variance in anti-tetanus immunoglobulin G levels based on LLPC enzyme-linked immunospot assay, we were unable to fit the same model with anti-spike antibodies, again pointing to the lack of LLPC contribution to circulating anti-spike antibodies. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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