Total Synthesis of Marine Macrolide Natural Products by the Macrocyclization/Transannular Pyran Cyclization Strategy.

Autor: Fuwa, Haruhiko
Předmět:
Zdroj: Synlett; Aug2024, Vol. 35 Issue 13, p1488-1499, 12p
Abstrakt: In this Account, we summarize the development of a new strategy for streamlined synthesis of tetrahydropyran-embedded macrolactones and its successful implementation to a 13-step synthesis of (–)-exiguolide and an 11-step synthesis of (+)-neopeltolide. 1 Introduction 2 Development of Macrocyclization/Transannular Pyran Cyclization Strategy 3 Total Synthesis of (–)-Exiguolide 4 Total Synthesis of (+)-Neopeltolide 5 Conclusions [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index