α-Lactalbumin mRNA-LNP Evokes an Anti-Tumor Effect Combined with Surgery in Triple-Negative Breast Cancer.

Autor:	He, Yun-Ru, Xia, Heng, Yun, Peng, Xu, Yuandong, Ma, Winson M. J., Xiao, Ze-Xiu, Zha, Gao-Feng
Předmět:	TRIPLE-negative breast cancer BREAST cancer surgery IMMUNOLOGIC memory VACCINE effectiveness TUMOR growth
Zdroj:	Pharmaceutics; Jul2024, Vol. 16 Issue 7, p940, 15p
Abstrakt:	Triple-negative breast cancer (TNBC) has been considered a huge clinical unmet need due to its aggressive progression and highly frequent metastasis. mRNA therapeutics supply a potential and versatile immunotherapy of oncology treatment. Here, we developed α-lactalbumin mRNA-lipid nanoparticles (α-LNP) as a potential therapeutical strategy for TNBC. The α-LNP induced the specific IgG antibodies and activated IFN γ-secreting-T cells in vivo. Additionally, the safety of α-LNP also had been demonstrated in vivo. When vaccinated prior to tumor implantation, α-LNP showed a preventive effect against 4T1 tumor growth and extended the survival of the tumor model by activating the memory immune responses. Furthermore, α-LNP administration in combination with surgical removal of neoplasm effectively inhibited the progression and metastasis in the TNBC model. Taken together, our results indicate that the α-LNP vaccine is a promising novel treatment for both therapeutics and prophylactics in TNBC. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
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