Diagnostics of Metabolic Bone Disease in Extremely Preterm Infants—Clinical Applicability of Bone Turnover Biochemical Markers and Quantitative Ultrasound.
| Autor: | Cerar, Sandra, Vurzer, Lara, Šalamon, Aneta Soltirovska, Kornhauser Cerar, Lilijana, Trdan, Matevž, Robek, Domen, Perme, Tina, Biček, Ajda, Oblak, Adrijana, Marc, Janja, Černe, Darko, Erčulj, Vanja, Grosek, Štefan |
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| Předmět: |
OSTEOPENIA
RISK assessment STATISTICAL correlation BONES REFERENCE values BONE density ACADEMIC medical centers CRITICALLY ill PATIENTS DATA analysis PREMATURE infant diseases PHOSPHATES SCIENTIFIC observation NEONATAL intensive care units MULTIPLE regression analysis LOGISTIC regression analysis BIOCHEMISTRY ULTRASONIC imaging ALKALINE phosphatase NEONATAL intensive care DESCRIPTIVE statistics TIBIA CALCIUM LONGITUDINAL method HOSPITAL care of newborn infants MEDICAL records ACQUISITION of data RESEARCH GESTATIONAL age STATISTICS COLLAGEN COMPARATIVE studies DATA analysis software LENGTH of stay in hospitals CONFIDENCE intervals BONE remodeling BIOMARKERS SENSITIVITY & specificity (Statistics) DISEASE risk factors CHILDREN |
| Zdroj: | Children; Jul2024, Vol. 11 Issue 7, p784, 14p |
| Abstrakt: | Background: Significant improvement in neonatal care has enabled increasing survival of preterm infants. Metabolic bone disease of prematurity is often overlooked due to other comorbidities of preterm birth. The best approach is screening and prevention of the disease in high-risk infants such as preterm infants. Aim: We followed up the clinical, radiological, and serum biochemical markers of metabolic bone disease in extremely preterm infants (<28 weeks of gestation). The clinical applicability and validation of C-terminal telopeptide of type I collagen (CTX-I) as a novel bone turnover marker were assessed. Standard and novel biochemical bone turnover markers and quantitative ultrasound were compared. Method: Patients' data were collected from medical records. Assessments of calcium, phosphate, alkaline phosphatase, bone-alkaline phosphatase, CTX-I, and quantitative ultrasound were prospectively performed twice in 42 extremely preterm infants at postmenstrual ages of 30–32 weeks and 36–40 weeks. Bone mineral density was measured by quantitative ultrasound. Conclusion: Phosphate, alkaline phosphatase, bone alkaline phosphatase, calcium, or ionized calcium are not related to gestational age, but bone mineral density, measured by quantitative ultrasound, is related. There is no correlation between standard and novel biochemical markers and quantitative ultrasound for the identification of metabolic bone disease. [ABSTRACT FROM AUTHOR] |
| Databáze: | Complementary Index |
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