| Autor: |
Arefan, Dooman, D'Ardenne, Nicholas M., Iranpour, Negaur, Catania, Roberta, Yousef, Jacob, Chupetlovska, Kalina, Moghe, Akshata, Sholosh, Biatta, Thangasamy, Senthur, Borhani, Amir A., Singhi, Aatur D., Monga, Satdarshan P., Furlan, Alessandro, Wu, Shandong |
| Předmět: |
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| Zdroj: |
Abdominal Radiology; Jul2024, Vol. 49 Issue 7, p2220-2230, 11p |
| Abstrakt: |
Purpose: Gain-of-function mutations in CTNNB1, gene encoding for β-catenin, are observed in 25–30% of hepatocellular carcinomas (HCCs). Recent studies have shown β-catenin activation to have distinct roles in HCC susceptibility to mTOR inhibitors and resistance to immunotherapy. Our goal was to develop and test a computational imaging-based model to non-invasively assess β-catenin activation in HCC, since liver biopsies are often not done due to risk of complications. Methods: This IRB-approved retrospective study included 134 subjects with pathologically proven HCC and available β-catenin activation status, who also had either CT or MR imaging of the liver performed within 1 year of histological assessment. For qualitative descriptors, experienced radiologists assessed the presence of imaging features listed in LI-RADS v2018. For quantitative analysis, a single biopsy proven tumor underwent a 3D segmentation and radiomics features were extracted. We developed prediction models to assess the β-catenin activation in HCC using both qualitative and quantitative descriptors. Results: There were 41 cases (31%) with β-catenin mutation and 93 cases (69%) without. The model's AUC was 0.70 (95% CI 0.60, 0.79) using radiomics features and 0.64 (0.52, 0.74; p = 0.468) using qualitative descriptors. However, when combined, the AUC increased to 0.88 (0.80, 0.92; p = 0.009). Among the LI-RADS descriptors, the presence of a nodule-in-nodule showed a significant association with β-catenin mutations (p = 0.015). Additionally, 88 radiomics features exhibited a significant association (p < 0.05) with β-catenin mutations. Conclusion: Combination of LI-RADS descriptors and CT/MRI-derived radiomics determine β-catenin activation status in HCC with high confidence, making precision medicine a possibility. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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