| Autor: |
Salimi, Saeedeh, Mohammadpour-Gharehbagh, Abbas, Hedayat, Mohaddeseh, Galavi, Hamidreza, Harati-Sadegh, Mahdiyeh |
| Zdroj: |
Personalized Medicine (17410541); May2024, Vol. 21 Issue 3, p191-204, 14p |
| Abstrakt: |
Aim: The authors designed a meta-analysis to find a comprehensive result of the impact of RNLS polymorphisms on preeclampsia (PE) susceptibility. Methods: The online databases PubMed, Scopus, and Google Scholar were employed for the purpose of literature search. Data analysis was conducted using STATA (ver. 12.0) and MetaGenyo web tool. Results: The findings showed that the RNLS rs10887800 polymorphism could increase risk of PE in allelic, codominant heterozygous and dominant genetic models. In addition, the analysis indicated that the RNLS rs2576178 polymorphism was associated with higher risk of PE in allelic, codominant homozygous, dominant, and recessive models. Conclusion: The findings of meta-analysis showed that the RNLS rs10887800 and rs2576178 polymorphisms could increase risk of PE in several genetic models. Summary points Renalase is a flavoprotein that is highly expressed in the kidney and heart and possibly has a significant role in blood pressure control. The association between rs2576178 and rs10887800 polymorphisms within the RNLS gene and susceptibility to preeclampsia (PE) has been assessed in various studies; however, the results have been inconsistent. Therefore, the current meta-analysis aimed to recognize a precise consequence about the effect of rs2576178 and rs10887800 on preeclampsia risk. Pooling data from seven studies for RNLS rs10887800 and five studies for RNLS rs2576178 utilizing STATA and MetaGenyo web tool showed that both of the mentioned polymorphisms were correlated with increased risk of PE under various genetic models. The findings strengthened the relationship between RNLS gene and PE development. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
|
